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Adjunct Professor

Sohn, Jong-woo

  • Neurophysiology
  • Electrophysiology
  • Appetite
  • Metabolism
  • Homeostasis

Biosketch

  • Jong-Woo Sohn is an associate professor at the department of biological sciences at KAIST. He received his M.D. and Ph.D. from Seoul National University College of Medicine. As a graduate student, he worked in the field of cellular neuroscience focusing on the regulation of ion channels. For postdoctoral studies, he moved to the University of Texas Southwestern Medical Center which Dr. Joel Elmquist directs, and expanded his expertise to include mouse genetics and neuroanatomical methods to study the neuronal circuit of appetite and metabolism. Since he started his lab at KAIST in 2014, his group is working to identify novel physiological functions assigned to GPCRs (e.g. serotonin 2C receptors, melanocortin-4 receptors) and the signaling molecules of the central nervous system, focusing primarily on their role in the maintenance of whole body physiology. These efforts will help to understand how our brain is monitoring changes of internal environment and maintain homeostasis.
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Key Papers

  • Ju SH, Yun H, Oh Y, Choi Y, Sohn JW. (2022) Melanocortin-4 receptors activate sympathetic preganglionic neurons and elevate blood pressure via TRPV1. Cell Reports, 41(5): 111579.
  • Li L, Wyler SC, Leon-Mercado LA, Xu B, Oh Y, Swati, Chen X, Wan R, Arnold AG, Jia L, Wang G, Nautiyal K, Hen R, Sohn JW*, Liu C*. (2022) Delineating a serotonin 1B receptor circuit for appetite suppression in mice. Journal of Experimental Medicine, 219(8): e20212307. (*co-corresponding authors)
  • Yoo ES, Li L, Jia L, Lord CC, Lee CE, Birnbaum SG, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW*, Liu C*. (2021) Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Reports, 37(7): 109997. (*co-corresponding authors)
  • Li L, Yoo ES, Li X, Wyler SC, Chen X, Wan R, Arnold AG, Birnbaum SG, Jia L, Sohn JW*, Liu C*. (2021) The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain. Journal of Experimental Medicine, 218(7): e20202484. (*co-corresponding authors)
  • Lee CH, Song DK, Park CB, Choi J, Kang GM, Shin SH, Kwon I, Park S, Kim S, Kim JY, Dugu H, Park JW, Choi JH, Min SH, Sohn JW*, Kim MS*. (2020) Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing hypothalamus. Nature Communications, 11(1): 5772. (*co-corresponding authors)
  • Park S, Williams KW, Liu C*, Sohn JW*. (2020) A neural basis for tonic suppression of sodium appetite. Nature Neuroscience, 23(3): 423-432. (*co-corresponding authors)

Courses

  • Physiology
  • Advanced Neurobiology
  • Biochemistry
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