Professor

Dr. Sung Ik Cho an Assistant Professor in the Department of Brain & Cognitive Sciences at KAIST, specializing in genome editing research.
He completed his doctoral studies with Dr. Jin-Soo Kim at the Department of Chemistry, Seoul National University, where I focused on genome editing and I received his Ph.D. in 2022. Subsequently, He did post-doctoral training with Dr. Hyongbum Kim at Yonsei University College of Medicine.
He has developed gene editing technologies not only for nuclear genes but also for genes in cellular organelles, such as mitochondria. During his graduate studies, he developed the world’s first mitochondrial adenine base editor and reported it.
His ultimate goal is to harness genome editing technologies to treat not only genetic disorders but also a wide range of other diseases. Genome editing represents an unprecedented and revolutionary technology that enables precise correction of defective genes. He aims to leverage this technology to contribute positively to the world through impactful research in the years to come.

Sung-Ik Cho*, Kayeong Lim*, Seongho Hong*, Jaesuk Lee, Annie Kim, Ji Min Lee, Young Geun Mok, Eugene Chung, Seunghun Han, Sang-Mi Cho, Jieun Kim, Sanghun Kim, Eun-Kyoung Kim, Ki-Hoan Nam, Yeji Oh, Minkyung Choi, Seonghyun Lee#, Hyunji Lee#, Jin-Soo Kim# (2024) Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA. Cell, 187, 95-109.e26 (2024). https://doi.org/10.1016/j.cell.2023.11.035
Sung-Ik Cho, Seonghyun Lee, Young Geun Mok, Kayeong Lim, Jaesuk Lee, Ji Min Lee, Eugene Chung and Jin-Soo Kim (2022) Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases. Cell, 185, 1764-1776.e12 (2022). https://doi.org/10.1016/j.cell.2022.03.039
Kayeong Lim*, Sung-Ik Cho* and Jin-Soo Kim (2022) Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases. Nature Communications, 13, 366 (2022). https://doi.org/10.1038/s41467-022-27962-0

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