Professor
Minee-Liane Choi
- Parkinson's
- Dimentia
- AI-based drug discovery
- Protein aggregation
- Mitochondrial dysfunction
- Cell death
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Education
PhD in Clinical Neurosciences, University of Cambridge (2013)
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Location
W13, 504
- Phone
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Laboratory
Brain Repair Laboratory
Biosketch
- Minee is a neurophysiologist specializing in neurodegenerative diseases. She currently serves as an assistant professor at the Department of Brain and Cognitive Science at KAIST. Additionally, she holds the distinguished position of Honorary Fellow at both the UCL Queen Square Institute of Neurology and the Francis Crick Institute in the UK.
- After obtaining BA and a MMSc degree from Hanyang University, she received the prestigious Cambridge Overseas Trust Scholarship, which enabled her to pursue a Ph.D. in Clinical Neurosciences at the University of Cambridge, under the supervision of a neurologist Professor Roger Barker. She successfully completed her PhD in Clinical Neurosciences in 2013.
- Following her doctoral studies, Minee continued her research career as a post-doctoral research fellow at University College London (UCL), where she worked in Professor John Wood's lab from 2013 to 2014 and later in Professor Sonia Gandhi's lab from 2014 to 2022. During this time, she also undertook a laboratory secondment at the Francis Crick Institute as a research scientist from 2017 to 2022. In February 2023, she was appointed as an assistant professor at KAIST.
- Minee's research is centered on understanding ofthe mechanisms underlying protein aggregation, mitochondrial dysfunction, and neuroinflammation in neurodegenerative diseases, such as Alzheimer's (AD) and Parkinson's disease (PD). Her work aims to dissect the cellular processes involved in neurodegeneration and develop personalized therapeutic approaches for AD and PD. She extensively employs patient-derived pluripotent stem cell (hiPSC) systems, human cellular models for studying mitochondrial dysfunction and protein aggregation, as well as machine learning techniques.
- Throughout her academic career, Minee has earned recognition for her contributions. She received the Imogen Rose Prize in 2010, awarded for her outstanding doctoral work at the University of Cambridge. The British Royal Society of Biology acknowledged her achievements in the field of neurodegeneration, granting her full membership in 2019. In 2021, she represented post-doctoral fellows of the British Neuroscience Association in the committee for the BNA 2021 conference. Furthermore, she served on the grant and fellowship committee of the Athena Swan program at the Crick Institute from 2019 to 2022, contributing to the empowerment of British female scientists. Since 2016, she has been an editorial board member for the Journal of Alzheimer's, Parkinsonism, and Dementia. Since her appointment at KAIST in February 2023, she has achieved notable recognition, including the KAIST Q-day Special Prize for Creative Talent in the same year, as well as the KAIST Outstanding Lecture Award in 2024.
Key Papers
- D'Sa K, Evans JR, Virdi GS, Vecchi G, Adam A, Bertolli O, Fleming J, Chang H, Leighton C, Horrocks M, Athauda D+, Choi ML+, Gandhi S+ "Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models" Nature Machine Intelligence, 11 Aug (2023) (+Equally contributed)
- Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, FedotovaE, Berezhnov AV, De S, Peddie C, Athauda D, Virdi GS, Zhang W, Evans JR, Angelova PR, Esteras N, Morris K, Tosatto L, Little D, Gissen P, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S “Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity” Nature Neuroscience 25, 1134–1148 (2022).
- Angelova PR*, Choi ML*, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S “Alphasynuclein aggregation drives ferroptosis in Parkinson’s disease: an interplayof iron, calcium and lipid peroxidation” Cell death & Differentiation. 27, 2781-2796 (2020) (*Equally contributed)
- Hughes CD*, Choi ML*, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D “Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play aninitiating role in Parkinson's disease pathogenesis” Acta Neuropathologica137(1), 103-120 (2019). (+Equally contributed)
- Hall, CE*, YaoZ*, Choi M*, Tyzack GE*, Serio A, Luisier R, Harley J, Preza E, Arber C, Crisp SJ, Watson PMD, Kullmann DM, Abramov AY, Wray S, Burley R, Loh SHY, Martins LM, Stevens MM, Luscombe NM, Sibley CR, Lakatos A, Ule J, Gandhi S, Patani R “Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS” CellReports 19(9), 1739-1749 (2017). (+Equally contributed)
Courses
- Biology of Neurons (BCS201 – Spring term)
- Laboratory in Animal Brain Anatomy and Physiology (BCS200 – Fall term)